Current Issue : July-September Volume : 2011 Issue Number : 3 Articles : 1 Articles
Recent estimates indicate that around 200 million people suffer from diabetes mellitus, making it the most common serious metabolic disorder worldwide [1]. Diabetes is characterized by hyperglycemia due to insufficient availability of, or insensitivity to insulin and is associated with slowly progressive end organ damage in the eyes, kidneys, blood vessels, heart and peripheral nerves, as well as in the brain. The current pharmacotherapeutic line presents many limitations as far as the efficacy, adverse effects and reversal rate in case of diabetic cognitive deficits in clinic. As oxidative stress plays pivotal role in the etiogenesis of cognitive deficit, antioxidants from natural origin particularly neutraceuticals are drawing attention of many researchers. . It is now well known fact that neutraceuticals can help in cognitive deficit acting not only through its antioxidant value but also demonstrate many potential avenues to overcome the clinical limitations of cognition enhancers. Present review is an attempt to throw light on the mechanistic approaches towards the diabetic cognitive deficits to have better understanding towards the route cause and thereby the treatment approach....
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